CHARACTERIZATION STUDIES ON A TETRAHYDROCURCUMIN-ZINC COMPLEX

Objective: Preparation and characterization studies on tetrahydrocurcumin complexed with zinc, particular reference to the location of zinc in complex. Methods: Structural characteristics its complex were compared using elemental analysis, mass spectrometry (MS), proton, carbon-13 nuclear magnetic resonance spectroscopy (NMR), ultraviolet-visible (UV) absorption spectroscopy, Fourier transform infrared (FTIR) spectroscopy. Results: MS data indicates a Zn molecule holds two THCur components together. NMR provide evidence that ion is associated 1,3-diketone part linker region THCur. FTIR consistent interaction enol tautomer at center UV indicate zinc-dependent shift absorbance maximum changes structure resulting from complexation zinc. Together, this linking molecules together by binding forms moieties located regions between aromatic rings. Conclusion: The spectral properties tetrahydrocurcumin-zinc are which encased moieties. Additional needed determine if results altered bioavailability, antioxidant activity other important for pharmaceutical development.